Response to Comment on “A commensal strain of Staphylococcus epidermidis protects against skin neoplasia” by Nakatsuji et al.

Kozmin et al. contend that observations previously reported regarding the antimicrobial and antitumor activities of 6-N-hydroxy aminopurine (6-HAP) were incorrect. Their conclusions rely on poorly characterized reagents and focus strictly on in vitro techniques without validation in relevant mammalian model systems. We are pleased to be able to illuminate the weaknesses in their technical comment. The totality of current results continues to support our original conclusion that a strain of the common human commensal skin bacterium, Staphylococcus epidermidis, produces 6-HAP that can inhibit tumor growth. In their technical comment (1), the authors report that they used a commercially available form of 6-N-hydroxy aminopurine (6-HAP) purchased from MP Biomedicals (Chemical Abstracts Service no. 5667-20-9). We will refer to this chemical as 6-HAP-MPB. The authors used this reagent to test in vitro mutagenic activity. To investigate their discrepancies with our findings, we purchased 6-HAP-MPB from this supplier and observed that the reagent upon which they based their conclusions is not 6-HAP. That 6-HAP-MPB is not 6-N-hydroxy aminopurine is obvious from the package label that sta...

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window.ntvConfig = window.ntvConfig || {} ; window.ntvConfig.keyValues = window.ntvConfig.keyValues || {}; var segs = localStorage.getItem(‘_pnativo’); if (segs) { window.ntvConfig.keyValues.permutive = JSON.parse(segs).join(“,”); } var prodNames = ”; var prodManufacturers = ”; var prodCategories = ”; var prodVendors = ”; var insiderSignedIn = document.cookie.indexOf(“nsdr”) > -1; //check if Insider cookie exists var idg_uuid = $.cookie(‘idg_uuid’) || ”; var dlJobFunction = ”; var dlJobPosition = ”; var dlIndustry = ”; if (insiderSignedIn) { var insiderToken = IDG.insiderReg.readCookie(“nsdr”); var tokens = IDG.insiderReg.readCookieProperty(insiderToken); if (!(tokens['jobPosition']===undefined)) { //dlJobPosition = tokens['jobPosition']; //OC-1647 change to indicate this data was remove dlJobPosition = “removed”; } if (!(tokens['jobFunction']===undefined)) { dlJobFunction = tokens['jobFunction']; } if (!(tokens['industry']===undefined)) { dlIndustry = tokens['industry']; } } insiderSignedIn = insiderSignedIn.toString(); //per Infotrust this needs to be a st...

Skender, IKEA Initiatives Bring Promise of Prefab Senior Housing Closer to Reality

Large players such as Skender and IKEA are betting that prefab building practices can help meet the rising demand for senior housing. Chicago-based Skender has morphed in the past 18 months from a general contractor to a vertically integrated manufacturer of prefabricated modular building components for multifamily, senior housing, health care and commercial buildings. The company cut the ribbon on a production facility on Chicago’s Southwest Side in February, and had its first prototype modular units built four months later. Skender has built senior living projects utilizing conventional methods and already is seeing interest from senior living developers in its prefab process. Meanwhile, Swedish furniture giant IKEA partnered with global construction firm Skanska to create Boklok, a prefabricated affordable housing arm that has built 11,000 homes in Sweden, Denmark and the United Kingdom. In June 2017, Boklok announced the launch of SilviaBo, a new type of prefabricated home for people with dementia, developed in conjunction with Queen Silvia of Sweden and her charitable foundation. And there are other signs that prefab and modular construction methods are poised to make an im...

2020 McLaren GT first drive review: Supercar heart, grand tourer finesse

Powerful, fast, comfortable and, yes, practical — this is truly the McLaren of exotic grand tourers. The McLaren GT might have the most straightforward name of all time, perhaps only behind the Renault Le Car. The latest trend for manufacturers of fun, fast or luxurious cars is to branch out and expand into the lucrative SUV market. But not at McLaren. Instead, the people in charge of McLaren Automotive have decided that what their customers want, in addition to their lineup of street- and track-focused supercars, is a grand tourer — a true McLaren GT. McLaren has dabbled in GTs before: The 570GT was a supercar with some token of practicality and the older Mercedes-Benz SLR McLaren was a fever dream of a bygone era. Yet the automaker says the aptly named McLaren GT is its first proper grand tourer. While McLaren initially set its sights on challenging manufacturers such as Ferrari and Lamborghini with its supercars, the GT takes aim at fellow Brits Aston Martin and Bentley. Both make cars that adhere to the list of requirements of a grand tourer: powerful, fast, comfortable, luxurious and with a certain degree of practicality and ease of use. The Aston Martin DB11 AM...

This Mercedes ML 6×4 is the six-wheeler you can afford

Ever since the Mercedes G63 AMG 6×6 reached production in 2013, six-wheelers have surfaced the web left and right. Carlex has created its own version of a 6×6 X-Class, while Hennessey went all crazy about it and added another axle to the Ford Raptor, giving birth to the VelociRaptor 6×6. But most of these monster trucks have one thing in common – a hefty price tag. I said ‘most’ as not all aren’t cheap. There’s the G63 AMG 6×6 clone from Japan that’s actually a Suzuki Jimny, while our favourite folks from Russia made a poor man’s 6×6 version of the Lada Niva. If these two cars don’t suit your taste, there’s one on eBay right now that might fit the bill: a Mercedes ML 6×4. Listed at £19,995, this converted Mercedes ML might very well be the most affordable six-wheeled Mercedes for sale right now. We specifically used “six-wheeler” as this Mercedes ML is actually a 6×4, with the working wheels presumably would be the original axles.  The Mercedes ML 6×4 is located in Nottingham, UK, but only a few details are found on its listing. Its title may say that it’s a Mercedes ML AMG...

BATON ROUGE, La. (WAFB) – For the last 34 years, Debra Fournet, owner of Party Paradise,

BATON ROUGE, La. (WAFB) – For the last 34 years, Debra Fournet, owner of Party Paradise, located on Drusilla Lane, has been ordering the usual. The usual is three 244 cubic foot helium tanks. But the last time she tried to re-up an order with her supplier, Praxair, just a few days before Mother’s Day she was stopped in her tracks. “They said, ‘Sorry, we don’t have any and actually we won’t be supplying you anymore with helium,’” Fournet said. That’s bad news for Fournet. At times, 30% of her sales come straight from those happy birthday balloons or a parent just hours away from celebrating graduation. “We’ve been hearing that for five years… that there was a helium shortage or going to be, but we never had any problems getting helium before,” Fournet explained. Quiet rumbles have now turned into reality. According to national reports, helium is in short supply, forcing up the price per tank or making it completely unavailable. She says these days, people hosting parties are into big numbers, like the 36-inch number and letter balloons. Fournet says during Mother’s Day weekend, they had a lot of orders to fill and were forced to turn down new orders because the...

Though they’re not much to look at, screws hold a place of honor in the construction,

Though they’re not much to look at, screws hold a place of honor in the construction, hobby, and furniture-making industries. From wall framing and cabinetmaking to everyday projects like building a wood bench, these lowly fasteners literally hold everything together—so it’s crucial that you choose and work with the right ones. The screw aisle at your local hardware store spans so long with seemingly endless options for this exact reason: Different projects require different types of screws. The more time you spend building and repairing around the house, you’ll get to know the following five types of screws—and when to use them—rather well. In the meantime, read on for a primer to help distinguish one variety from another and simplify your next trip to the hardware store. Before we talk about which types of screws are right for the specific projects on your to-do list, let’s talk about how most screws are inserted today. For best grip, the design on the screw head coordinates with a specific screwdriver or power drill‘s bit. Take Phillips screws, developed by the Phillips Screw Company, as an example: This popular fastener is easily recognizable by the “+” on its head and requi...

Spiral Welded Pipe Market Revenue tops Estimates | Eyes Robust Growth Rate Ahead

Global Spiral Welded Pipe study will help you investigate a detailed division of the market by the end user/industry, by best in class product type and by geography with creation, income, utilization, export & import data in these areas, crunching historical data along with primaries and opinion leaders and industry experts interview and estimate with detailed driving factors for forcasted period.Get Sample Report PDF With More Details And Graph @ https://www.htfmarketreport.com/sample-report/1513480-global-spiral-welded-pipe-market-4 The Global Spiral Welded Pipe is relied upon to come to an expected $XX.X billion by 2025 and it is a gauge to develop at a CAGR of X.X% for forecast period. This report centers around top makers in the Global Spiral Welded Pipe, with generation, value, income, and market share for every producer/manufacturers. Top Spiral Welded Pipe Manufacturers:EVRAZ, Baoji Petroleum Steel Pipe, JFE, Jindal SAW Ltd, EUROPIPE Group, Essar Steel, Jiangsu Yulong Steel Pipe, American SpiralWeld Pipe Company, Zhejiang Kingland & Tenaris. Spiral Welded Pipe Report Focusing By Applications:Crude Oil Transmission, Natural Gas Transmission & Refined Products ...

Bailey Caravans Alicanto Grande Porto – For Sale – New & Used Caravans & Caravanning Reviews

News, views, offers, competitions – sign up to our email newsletters for the latest in motorhomes, caravans, shows, camping and more. Hide message. Set a mile from the north Norfolk coast in an Area of Outstanding Natural Beauty, Kelling Heath is an environmentally aware 300-acre holiday park offering a wide range of activities for all the … End the season in style at our season finale! Camping, ‘Best of British’ entertainment, shop the sales, themed displays, historic Lincoln nearby and more. Organised by Warners Shows and the Three Counties Showground – this is your chance to enjoy a great value weekend break in the wonderful Malvern Hills. Day Tickets also available. Yorkshire’s biggest motorhome and accessory show returns to Harrogate, with hundreds of new and used models plus an accessories megastore. Decorative L Brackets Manufacturers Cheap Price We use cookies to improve your experience of this website by remembering your usage preferences, collecting statistics, and targeting relevant content. If you continue to use this site we’ll assume you’re happy to receive all cookies. Shelf Bracket, Drawer Slider, Bed Hinge, Tower Bolt, Corner Brack...

The BetterBack from ‘Shark Tank’ has eliminated my back pain and posture problems at work

Take it from someone with two slipped discs in her spine — sitting at a desk all day is no walk in the park. In fact, sometimes my back is in so much pain that an actual walk in the park is no walk in the park, either. According to the American Chiropractic Association, half of all working Americans experience some form of back pain — including the youngest rung of the workforce. That means the “aching backs” we used to hear about from our parents now often apply to us, too. This is often a result of the poor posture that desk jobs cause us to develop. I know for a fact that I’m not the only 26-year-old with bad posture, but there aren’t quite as many people my age who also suffer from severe and chronic back pain. In addition to things like stretch, yoga, chiropractic treatment, physical therapy, and massage, I’ve tried a ton of different ergonomic chairs, quite a few back rests, seat cushions, balance balls, etc. to combat the constant stress on my back that’s caused by my slipped discs and generally terrible posture. After dumping way too much money into treatments that didn’t help much, I found one thing that has worked for me — a $6...

Waves Review: A Formidable Current of Mostly Unilluminating Formalist Tricks

This is a rare case of a film that’s stronger when it colors inside the lines than radically traces outside of them. Writer-director Trey Edward Shults’s Waves begins in motion, with shots kinetically circling and tracking its young characters. Along with the film’s editing—which is timed throughout to endless music cues, be they pop songs or the muffled industrial moans and staggered beats of Trent Reznor and Atticus Ross’s score—Shults is quick to establish Tyler’s (Kelvin Harrison Jr.) bona fides as a dedicated student and wrestler. The filmmaker also highlights the luxury in which the teen lives, from his huge home to the brand new cars that his parents and their children drive. Tyler immediately comes across as a kid who has it all, including the love of an adoring girlfriend, Alexis (Alexa Dernie). Efficient as it is as an introduction to Tyler, the montage that opens the film also simplifies the young man—namely, to all the good things in his life. Defining a character by what he has makes it all too easy to create the sort of drama that exists to strip all of those things away, which Waves proceeds to do in such quick and overwhelming fashion that Tyler starts to resemb...

Blowing Rock pickleball players ask for permanent courts in Memorial Park | News

Scattered thunderstorms in the morning, then mainly cloudy during the afternoon with thunderstorms likely. High near 75F. Winds light and variable. Chance of rain 80%.. The lower basketball court, also set up pickleball, in Blowing Rock’s Memorial Park is currently under renovation with a pathway, left, being constructed, as pictured on Sept. 10. Ellen Bray speaks to the Blowing Rock Town Council on Sept. 10, asking them for permanent pickleball courts in Memorial Park. The lower basketball court, also set up pickleball, in Blowing Rock’s Memorial Park is currently under renovation with a pathway, left, being constructed, as pictured on Sept. 10. Ellen Bray speaks to the Blowing Rock Town Council on Sept. 10, asking them for permanent pickleball courts in Memorial Park. BLOWING ROCK – Several Blowing Rock residents asked the Blowing Rock Town Council during its Sept. 10 meeting for the lower basketball court in Memorial Park to be transformed into three full-time pickleball courts. “It’s the fastest growing sport in the country,” said resident Lee Cohen. “It’s big among baby boomers.” Cohen, Ellen Bray and Mike Catanese each gave public comments asking for the permanent courts, ...

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